منابع مشابه
Thyroxine Degradation. Iii. Competitive Inhibition of Thyroxine Degradation; Relationship of Structure to Inhibition.
Few attempts have been made to relate the structure of substances deiodinated by the systems in vitro which degrade thyroxine to specific structural requirements necessary for the reaction. In general, it has been found that several thyronine derivatives may be degraded by the rabbit muscle or rat liver microsomal thyroxine-degrading systems, but that none is more efficiently degraded than thyr...
متن کاملThyroxine degradation during lipoxidase-catalyzed peroxidation of linoleic acid.
The possibility has been examined that thyroxine may be degraded by an intermediate free radical in the oxidation of linoleate catalyzed by lipoxidase. Such a reaction has been observed and the lipid radical with which thyroxine reacts is suggested to be enzyme attached RO; proposed by Tappel (in W. 0. LUIVDBERG (Editor), A&oxidation and antioxidants, Vol. I, Interscience Publishers, New York, ...
متن کاملEffective thyroxine ratio and free thyroxine index
Brien, T. G., Fay, J. A., and Griffin, E. A. (1974). Archives of Disease in Childhood, 49, 225. Thyroid status in the newborn infant: effective thyroxine ratio and free thyroxine index. The effective thyroxine ratio (ETR) was determined in 28 term and 17 premature infants at birth and in 17 infants aged 0 to 6 weeks. The mean values found were significantly higher than those in 20 adult euthyro...
متن کاملProtein synthesis and degradation during regression of thyroxine-induced cardiac hypertrophy.
To characterize changes in rates of protein turnover during regression of thyroxine-induced left ventricular hypertrophy, New Zealand White rabbits received intravenous thyroxine (200 micrograms/kg/d) for 9 days. Thyroxine was withheld, and in vivo protein turnover was evaluated on the 10th, 15th and 20th days. Animals not receiving thyroxine served as controls. Heart rate, blood pressure, and ...
متن کاملThyroxine-protein interactions. Interaction of thyroxine and triiodothyronine with human thyroxine-binding globulin.
The effect of temperature on the binding of thyroxine and triiodothyronine to thyroxine-binding globulin has been studied by equilibrium dialysis. Inclusion of ovalbumin in the dialysis mixture stabilized thyroxine-binding globulin against losses in binding activity which had been found to occur during equilibrium dialysis. Ovalbumin by itself bound the thyroid hormones very weakly and its bind...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1962
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)73954-4